Sakura Tissue-Tek® Cryo3® Flex Cryostat

Innovative technology


The Tissue-Tek® Cryo3® Flex Cryostat is the 3rd generation of the established, reliable and trusted Cryo3 platform for fast sectioning of frozen tissue specimens. It was designed to decrease the time to get complete sections, and in parallel to preserve valuable tissue.

The Tissue-Tek® Cryo3® Flex Cryostat produces superior sections from 1 to 99 µm using a temperature-controlled blade holder and a 3D Precision Chuck to accurately align the block face to the blade, reducing operator’s trimming time and preserving specimens. The sturdy chuck retains its position when locked and unlocked, eliminating any time and effort spent realigning the cutting angle.

Users can now leverage the newly developed Anti-Roll Rake that was designed to best mimic the preferred and widely accepted “Brush Technique” to prevent sections from rolling, which in addition, reduces the learning curve of new users making them proficient faster.

For the first time in the history of cryotomy, Sakura successfully integrated its advanced remote diagnostics technology platform, iSupport, into the hardware and software of the Cryo3 Flex. The plug-and-play connection opens communication to a secure remote service that ensures maximum uptime through fast reaction to instrument alerts by Sakura’s professional technical support team.

A color touch LCD screen provides a visual display of critical sectioning information such as current chamber temperature, section thickness, and trimming thickness.  The Cryobar® offers 12 positions, allowing operators to use the Cryomold® method or direct method at the same time.  The Cryo+™ area of the Cryobar freezes to -50 C, within 5 minutes after activation.

The motorized advance and retract keys allows smooth, precise orientation of the 3D Precision Chuck to the blade holder. The blade holder accommodates Accu-Edge® high and low-profile disposable blades.

The Tissue-Tek Cryo3 Flex D and DM models offer innovative options like motorized sectioning, ozone disinfection, and a vacuum debris removal system. The Cryo3 Flex now uses a more efficient and patented ozone technology to safely protect operators from pathogens in between weekly decontamination requested by CAP Accreditation Guidelines. The combination of ozone, UV and elevated temperatures provide unprecedented disinfection with a reduction of up to 5 logs for the SV40 virus.

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